Generic name: Moclobemide
Brand name: Manerix (USA/Canada)
Aurorix or Rimarex (Australia/Europe)
Another commonly used name is RO 11-1163.
Drug monograph
Serotonin or 5-HT
In the body, 5-HT is involved with blood pressure and gut control.
In the brain, it controls mood, emotions, sleep/wake, feeding, temperature regulation, etc.
Too much serotonin and you feel sick, less hungry, get headaches or migraines. Too little and you feel depressed, drowsy etc.
HOW MOCLOBEMIDE PROBABLY WORK
If too little serotonin or noradrenaline produces the symptoms of depression then correcting this should help to reduce the symptoms. One way of doing this is to stop the breakdown of transmitters. This is just what moclobemide does. It blocks the monoamine oxidase enzyme which breaks down the transmitter, so the next time an impulse comes along, there is more transmitter, a stronger message is passed, and activity in that part of the brain is increased.
The important thing to remember is that antidepressants probably mainly work by correcting the effect of having too little transmitter. They are NOT JUST STIMULANTS. They have a much more specific way of working than just stimulating you.
WHY YOU GET SIDE EFFECTS FROM MOCLOBEMIDE
Some antidepressants e.g. the tricyclics, block the reuptake of serotonin and noradrenaline. Others mainly block the reuptake of just serotonin e.g. the SSRIs. Moclobemide blocks the monoamine enzyme which breaks down noradrenaline, serotonin and some other transmitters. This is the same affect as the MAOIs (Monoamine Oxidase Inhibitors), but moclobemide is slightly different. It is often referred to as a RIMA (Reversible Inhibitor of Monoamine Oxidase A) i.e. there are two monoamine oxidase enzymes (A and B) and moclobemide blocks only the A enzyme, and it blocks it reversibly, rather than irreversibly.
One of the problems with the traditional MAOIs (e.g. tranylcypromine, isocarboxazid, phenelzine) is that they also block the monoamine oxidase enzyme in the body which breaks down other compounds. One of these is an amino acid called tyramine.
Tyramine is an essential compound which the body needs, and is found in many foods. However, if you have too much tyramine in the body, it can make your blood pressure rise. Foods such as cheese, yeast and meat extracts etc contain lots of tyramine. If you eat any of these foods while taking an MAOI, your body can not break down (or metabolise) the tyramine. You then get an excess of tyramine in the body, which increases your blood pressure very quickly. This can cause headaches initially but can be very dangerous and has caused many deaths.
Moclobemide blocks only the A enzyme, and because it is reversible, if you eat any foods containing tyramine, the moclobemide gets pushed off the enzyme, which can then metabolise any potentially dangerous tyramine. If you were to eat huge amounts of tyramine, you could possibly get an adverse effect, but under usual dietary circumstances this is highly unlikely.
Moclobemide also affects other transmitters which are broken down by the MAO enzyme.
* Affecting your noradrenaline may also sometimes
upset your blood pressure
e.g. you may feel dizzy when you stand up etc.
BACK to
Manerix-1
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COMMENT
This drug CANNOT be made chemically in the laboratory.
It is manufactured in mice which have been genetically found to produce a high level of it.
In a small number of batches, a largely harmless rodent virus is captured with the pharmaceutical ingredient and ends up in the tablet batch. This virus cannot be currently (2003) tested for and excluded. It is the source for the possible viral side effects listed for Manerix, including fever. This manufacturing information has been removed from the Internet in an effort to address naive and paranoid concerns.
5-HTP is a good substitute for this drug if being taken for Depression, or, Candidiasis and it will alter the serotonin level in positive ways to counter those. In the case of the much more powerful FUIRERIA, I know of nothing other than large, muscle tested or Spiritually Guided doses which are part of an effective response.
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